Which statement is an advantage of compound-centered drug design?

• A. It guarantees successful drug discovery.
• B. Natural products have a reasonable likelihood of biologic activity.
• C. Isolation from natural sources is always harder than synthesis.
• D. Synthetic refinement is unnecessary.

Answer: (B)

Natural products often have a higher chance of biological activity because they evolved to interact with biological targets, which makes them valuable starting points in compound-centered drug design. This approach uses known chemical scaffolds and structure–activity relationships to optimize compounds, so starting with natural products can give you hits that are more likely to show meaningful activity and guide further refinement. The idea is not that every natural product will be a drug, but that their evolved bioactivity makes them productive leads, improving the odds of finding a useful compound. The other statements aren’t advantages: no method guarantees success, isolation from nature isn’t always harder than synthesis, and synthetic refinement is still a standard, not unnecessary, step.