Which statement about Type E ADRs is true?

• A. They are uncommon
• B. They are often dose related
• C. They are unpredictable
• D. They require hospitalization in all cases

Answer: (A)

Type E ADRs are withdrawal phenomena that occur when a drug is stopped after prolonged or dependent use. They aren’t driven by the dose that was taken in a straightforward way; instead, they reflect the body’s adaptation to the drug and the effects of ending exposure. Because withdrawal happens only with drugs that people become dependent on and only after stopping, these reactions are relatively uncommon compared with other ADR types that are more routinely dose-related or unpredictable. They aren’t inherently unpredictable—if a drug is known to cause withdrawal, clinicians anticipate it and often plan a taper to minimize symptoms. And they don’t require hospitalization in all cases; many withdrawal symptoms can be managed with gradual tapering, supportive care, and outpatient monitoring. Examples include benzodiazepine withdrawal after long-term use, opioid withdrawal after stopping opioids, and discontinuation syndromes with some antidepressants.