What percentage range describes drugs metabolized by CYP2D6?

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Multiple Choice

What percentage range describes drugs metabolized by CYP2D6?

Explanation:
CYP2D6 metabolizes roughly 20–30% of clinically used drugs. This range reflects its role as an important, but not predominant, pathway for drug metabolism. While enzymes like CYP3A4 handle the largest share of substrates, CYP2D6 still contributes significantly to many antidepressants, antipsychotics, beta-blockers, and prodrugs such as codeine. Individual genetic variability in CYP2D6 can change a person’s response to these drugs (poor vs. rapid metabolizers), but the overall proportion of drugs that rely on this enzyme remains within the 20–30% range.

CYP2D6 metabolizes roughly 20–30% of clinically used drugs. This range reflects its role as an important, but not predominant, pathway for drug metabolism. While enzymes like CYP3A4 handle the largest share of substrates, CYP2D6 still contributes significantly to many antidepressants, antipsychotics, beta-blockers, and prodrugs such as codeine. Individual genetic variability in CYP2D6 can change a person’s response to these drugs (poor vs. rapid metabolizers), but the overall proportion of drugs that rely on this enzyme remains within the 20–30% range.

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