What is an example of a Type F ADR?

• A. Resistance to antimicrobial agents
• B. Opiate withdrawal
• C. Withdrawal reaction
• D. End of use exposure

Answer: (D)

Type F ADRs are adverse effects that occur when a drug is discontinued—the response is tied to the end of exposure and often reflects rebound or withdrawal phenomena as the body readjusts without the drug. End of use exposure is the clearest example because it directly captures adverse outcomes that arise after stopping therapy. It isn’t about the drug working poorly or a drug–drug interaction; rather, it’s about what happens when the drug is no longer present. The other options don’t illustrate this timing: resistance to antimicrobial agents is a microbial issue, not an adverse reaction in the patient, and withdrawal-related effects are indeed about stopping a drug but the succinct illustration of Type F is the end of exposure itself.