Prevalence of slow acetylator phenotype in Ethiopian population?

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Multiple Choice

Prevalence of slow acetylator phenotype in Ethiopian population?

Explanation:
In pharmacogenetics, how rapidly people acetylate drugs is driven by NAT2 genotype. Slow acetylators have reduced NAT2 enzyme activity, so drugs that rely on NAT2 for clearance stay in the body longer, increasing exposure and risk of toxicity if standard doses are used. The frequency of slow acetylators varies by ethnicity, and in Ethiopian populations it is particularly high—reported to be around 90%. This reflects common NAT2 alleles that reduce enzyme activity (like NAT2*5, NAT2*6, NAT2*7) being prevalent there. So the prevalence being about 90% is consistent with the known NAT2 distribution in Ethiopians.

In pharmacogenetics, how rapidly people acetylate drugs is driven by NAT2 genotype. Slow acetylators have reduced NAT2 enzyme activity, so drugs that rely on NAT2 for clearance stay in the body longer, increasing exposure and risk of toxicity if standard doses are used. The frequency of slow acetylators varies by ethnicity, and in Ethiopian populations it is particularly high—reported to be around 90%. This reflects common NAT2 alleles that reduce enzyme activity (like NAT25, NAT26, NAT2*7) being prevalent there. So the prevalence being about 90% is consistent with the known NAT2 distribution in Ethiopians.

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